CD16 antibody

Catalog No. ABIN1176930

This anti-CD16 antibody is a Mouse Monoclonal antibody detecting CD16 in FACS. Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for CD16 antibody (ABIN1176930)

Target: CD16

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD16 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: 3G8

Product Details anti-CD16 Antibody

Brand: BD Pharmingen™

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Sterility: 0.2 μm filtered

Endotoxin Level: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Immunogen: Human polymorphonuclear leukocytes

Isotype: IgG1 kappa

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Preservative: Azide free

Storage: 4 °C

Storage Comment: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

References for anti-CD16 antibody (ABIN1176930)

Wirthmueller, Kurosaki, Murakami, Ravetch: "Signal transduction by Fc gamma RIII (CD16) is mediated through the gamma chain." in: The Journal of experimental medicine, Vol. 175, Issue 5, pp. 1381-90, (1992) (PubMed).

Target Details for CD16

Target: CD16

Alternative Name: CD16

Background: The 3G8 monoclonal antibody specifically binds to the 50-65 kDa transmembrane form of the IgG Fc Receptor (FcgammaRIII), a human NK-cell-associated antigen. CD16 is expressed on NK cells as well as macrophages and granulocytes. Reports indicate that CD16 plays a role in signal transduction and NK cell activation. The 3G8 antibody blocks the binding of soluble immune complexes to granulocytes.
Synonyms: FcRIII, Fc-gamma RIII, FCG3, FCGR3, FCGRIII, FcgammaRIII, IGFR3

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process